Sinkfingerprotein 695

ZNF695
Identifikatorar
Andre namn	ZNF695, SBZF3, zinc finger protein 695
Eksterne ID-ar	OMIM: 616348 HomoloGene: 130710 GeneCards: ZNF695
Genplassering (menneske)
Kromosom	Menneskekromosom 1
Ende	247,008,093 bp
RNA-uttrykksmønster
	Top expressed in
	kjønnskjertel; ; testikkel; ; ganglionic eminence; ; ventricular zone; ; nervus suralis; ; stromal cell of endometrium; ; mucosa of transverse colon; ; morkake; ; endetarm; ; beinmerg;
	Meir referanseuttrykksdata
	n/a
Genontologi
Molekylær funksjon	metallionebinding; nukleinsyrebinding; GO:0001948, GO:0016582 proteinbinding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Sellekomponent	intracellulærrom; cellekjerne;
Biologisk prosess	GO:0009373 regulation of transcription, DNA-templated; GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Kjelder:Amigo / QuickGO
Ortologar
	57116
	n/a
	ENSG00000197472
	n/a
	Q8IW36
	n/a
	NM_001204221; NM_020394
	n/a
	NP_001191150; NP_065127
	n/a
	Wikidata
sjå/endra menneske

Sinkfingerprotein 695 er eit protein som hos menneske er koda for av genet ZNF695.^[3] Det høyrer til underfamilien C2H2 i sinkfingerfamilien.^[4] Proteinet inneheld fleire KRAB-domene, som er typisk for repressorprotein.^[4] Genet er truleg involvert i transkripsjonsregulering,^[5] og merkte seg ut som eit av fleire overuttrykte gen i maligne eggstokksvulstar og ovariske kreftcelleliner.^[4]

Kjelder

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000197472 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «ZNF695 zinc finger protein 695 [ Homo sapiens (human) ]». Gene. National Center for Biotechnology Information. 4. juni 2017. Henta 2. juli 2017.
↑ ^4,0 ^4,1 ^4,2 Juárez-Méndez S, Zentella-Dehesa A, Villegas-Ruíz V, Pérez-González OA, Salcedo M, López-Romero R; et al. (2013). «Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer.». J Ovarian Res 6 (1): 61. PMC 3847372. PMID 24007497. doi:10.1186/1757-2215-6-61.
↑ «ZNF695 Gene». GeneCards: The Human Gene Database. Weizmann Institute of Science. Henta 2. juli 2017.

Takahashi T, Yamahsita S, Matsuda Y, Kishino T, Nakajima T, Kushima R, Kato K, Igaki H, Tachimori Y, Osugi H, Nagino M, Ushijima T (2015). «ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy». J. Cancer Res. Clin. Oncol. 141 (3): 453–63. PMID 25273507. doi:10.1007/s00432-014-1841-x.
Juarez-Mendez S, Zentella-Dehesa A, Villegas-Ruiz V, Perez-Gonzalez OA, Salcedo M, Lopez-Romero R, Roman-Basaure E, Lazos-Ochoa M, Montes de Oca-Fuentes VE, Vazquez-Ortiz G, Moreno J (2013). «Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer». J Ovarian Res 6 (1): 61. PMC 3847372. PMID 24007497. doi:10.1186/1757-2215-6-61.
Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N; et al. (2014). «A proteome-scale map of the human interactome network.». Cell 159 (5): 1212–26. PMC 4266588. PMID 25416956. doi:10.1016/j.cell.2014.10.050.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A; et al. (2006). «The DNA sequence and biological annotation of human chromosome 1.». Nature 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.