Proteinet OS-9

OS9
Tilgjengelege strukturar
PDB	Ortologsøk: PDBe RCSB
Liste over PDB-ID-kodar
	3AIH
Identifikatorar
Andre namn	OS9, ERLEC2, OS-9, endoplasmic reticulum lectin, OS9 endoplasmic reticulum lectin
Eksterne ID-ar	OMIM: 609677 MGI: 1924301 HomoloGene: 31409 GeneCards: OS9
Genplassering (menneske)
Kromosom	Menneskekromosom 12
Ende	57,721,557 bp
Genplassering (mus)
Kromosom	Musekromosom 10
Ende	126,957,000 bp
RNA-uttrykksmønster
	Top expressed in
	akillessene; ; tendo musculus biceps brachii; ; stromal cell of endometrium; ; monocytt; ; granulocytt; ; body of pancreas; ; Dei langerhanske øyane; ; liten spyttkjertel; ; right lobe of thyroid gland; ; mucosa of ileum;
	Meir referanseuttrykksdata
	; ;
	More reference expression data
Genontologi
Molekylær funksjon	binding av karbohydrat; GO:0001948, GO:0016582 proteinbinding; proteasebinding;
Sellekomponent	Hrd1p ubiquitin ligase complex; ER-lumen; ER-membran; endoplasmic reticulum quality control compartment; endoplasmatisk retikulum;
Biologisk prosess	proteinsortering; protein retention in ER lumen; negative regulation of retrograde protein transport, ER to cytosol; protein ubiquitination; ubiquitin-dependent ERAD pathway; response to endoplasmic reticulum stress; endoplasmic reticulum mannose trimming; transmembrantransport; ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol;
	Kjelder:Amigo / QuickGO
Ortologar
	10956
	216440
	ENSG00000135506
	ENSMUSG00000040462
	Q13438
	Q8K2C7
NM_001017956; NM_001017957; NM_001017958; NM_001261420; NM_001261421;
	NM_001261422; NM_001261423; NM_006812
	NM_001171026; NM_177614
NP_001017956; NP_001017957; NP_001017958; NP_001248349; NP_001248350;
	NP_001248351; NP_001248352; NP_006803
	NP_001164497; NP_808282
	Wikidata
sjå/endra menneske	sjå/endra mus

OS-9 er eit lektin som er involvert i endoplasmatisk retikulum-assosiert degradering (ERAD) av misfalda protein. Det kjenner att N-glykan som saknar den siste mannoseresten på C-greina. Det har eitt mannose-6-fosfat-reseptorhomologi (MRH)-domene.^[5]

I ERAD-prosessen leverer OS-9 misfalda protein til proteinet SEL1L. SEL1L er ein del av eit dislokon som fører misfalda protein over membranen til endoplasmatisk retikulum og ut i cytosol, der dei kan brytast ned av proteasom eller av avgrensa autofagi.^[6]

Kjelder

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000135506 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000040462 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hosokawa, Nobuko; Kato, Koichi; Kamiya, Yukiko (2010). «Mannose 6-Phosphate Receptor Homology Domain-Containing Lectins in Mammalian Endoplasmic Reticulum-Associated Degradation». Glycobiology. Methods in Enzymology 480. s. 181. ISBN 9780123809995. doi:10.1016/S0076-6879(10)80010-2.
↑ Roth, Jürgen; Zuber, Christian (2016). «Quality control of glycoprotein folding and ERAD: The role of N-glycan handling, EDEM1 and OS-9». Histochemistry and Cell Biology 147 (2): 269. PMID 27803995. doi:10.1007/s00418-016-1513-9.

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[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000135506 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000040462 - Ensembl, May 2017

[3] «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hosokawa2010-5] Hosokawa, Nobuko; Kato, Koichi; Kamiya, Yukiko (2010). «Mannose 6-Phosphate Receptor Homology Domain-Containing Lectins in Mammalian Endoplasmic Reticulum-Associated Degradation». Glycobiology. Methods in Enzymology 480. s. 181. ISBN 9780123809995. doi:10.1016/S0076-6879(10)80010-2.

[Roth2017-6] Roth, Jürgen; Zuber, Christian (2016). «Quality control of glycoprotein folding and ERAD: The role of N-glycan handling, EDEM1 and OS-9». Histochemistry and Cell Biology 147 (2): 269. PMID 27803995. doi:10.1007/s00418-016-1513-9.

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