Proteolipidprotein

PLP1
Tilgjengelege strukturar
PDB	Ortologsøk: PDBe RCSB
Liste over PDB-ID-kodar
	2XPG
Identifikatorar
Andre namn	PLP1, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2, proteolipid protein 1
Eksterne ID-ar	OMIM: 300401 MGI: 97623 HomoloGene: 448 GeneCards: PLP1
Genplassering (menneske)
Kromosom	Menneskekromosom X
Ende	103,792,619 bp
Genplassering (mus)
Kromosom	Musekromosom X
Ende	135,740,482 bp
RNA-uttrykksmønster
	Top expressed in
	gyrus frontalis medius; ; corpus callosum; ; inferior ganglion of vagus nerve; ; superior vestibular nucleus; ; hjernebru; ; nucleus subthalamicus; ; ventral tegmental area; ; ryggmerg; ; 1. cervikalsegment; ; pars reticulata;
	Meir referanseuttrykksdata
	More reference expression data
Genontologi
Molekylær funksjon	GO:0001948, GO:0016582 proteinbinding; structural constituent of myelin sheath; structural molecule activity; identical protein binding;
Sellekomponent	integral component of membrane; myelinskjede; cellemembran; membran;
Biologisk prosess	axon ensheathment; integrin-mediated signaling pathway; astrocyte development; myelination; utvikling av akson; GO:1901313 positiv regulering av genekspresjon; inflammatorisk respons; glial cell differentiation; cellemodning; long-chain fatty acid biosynthetic process; substantia nigra development; central nervous system myelination; synaptisk transmisjon; neuron projection development;
	Kjelder:Amigo / QuickGO
Ortologar
	5354
	18823
	ENSG00000123560
	ENSMUSG00000031425
	P60201
	P60202
	NM_199478; NM_000533; NM_001128834; NM_001305004
NM_011123; NM_001290561; NM_001290562; NM_001359117; NM_001359118;
	NM_001359119; NM_001359120
	NP_000524; NP_001122306; NP_001291933; NP_955772
NP_001277490; NP_035253; NP_001346046; NP_001346047; NP_001346048;
	NP_001346049
	Wikidata
sjå/endra menneske	sjå/endra mus

Proteolipidprotein er eit transmembranprotein som utgjer 17 % eller meir av proteininnhaldet i myelinet i sentralnervesystemet.^[5] Det vert koda for av PLP1-genet på X-kromosomet. PLP1-genet vert i hovudsak uttrykt i vaksne oligodendrocyttar,^[6] der 10 % av bodberar-RNA-et ved myelinisering er avskrifter av PLP1-genet.^[7] Dei to isoformene PLP og DM20 av proteolipidprotein er vanlege i myelinet i sentralnervesystemet.^[8] Andre isoformer vert uttrykte i hovudsak i nerveseller i sentralnervesystemet.^[9]

Mutasjonar i PLP1-genet valdar Pelizaeus-Merzbacher-sjukdomen.^[9]

Homologar av proteolipidprotein finst hjå mange artar, mellom anna hjå haiar og skater. Proteolipidprotein fekk truleg rolla som eit myelinprotein tidleg i utviklinga av ryggradsdyr. Proteolipidproteina M6A og M6B frå husmus har homologar hjå ryggradslause dyr, mellom anna bananfluge.^[10]

Kjelder

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000123560 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000031425 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jahn, Olaf; Tenzer, Stefan; Werner, Hauke B. (2009). «Myelin Proteomics: Molecular Anatomy of an Insulating Sheath». Molecular Neurobiology 40 (1): 55–72. PMC 2758371. PMID 19452287. doi:10.1007/s12035-009-8071-2.
↑ Torii, Tomohiro; Miyamoto, Yuki; Yamauchi, Junji; Tanoue, Akito (2014). «Pelizaeus-Merzbacher disease: Cellular pathogenesis and pharmacologic therapy». Pediatrics International 56 (5): 659. PMID 25040584. doi:10.1111/ped.12450.
↑ Baumann, N; Pham-Dinh, D (2001). «Biology of oligodendrocyte and myelin in the mammalian central nervous system». Physiological reviews 81 (2): 871–927. PMID 11274346.
↑ Daffu, Gurdip; Sohi, Jasloveleen; Kamholz, John (2012). «Proteolipid protein dimerization at cysteine 108: Implications for protein structure». Neuroscience Research 74 (2): 144. PMID 22902553. doi:10.1016/j.neures.2012.07.009.
↑ ^9,0 ^9,1 Sarret, C.; Combes, P.; Micheau, P.; Gelot, A.; Boespflug-Tanguy, O.; Vaurs-Barriere, C. (2010). «Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene». Neuroscience 166 (2): 522. PMID 20036320. doi:10.1016/j.neuroscience.2009.12.047.
↑ Schweitzer, Jörn; Becker, Thomas; Schachner, Melitta; Nave, Klaus-Armin; Werner, Hauke (2006). «Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence». Molecular and Cellular Neuroscience 31 (1): 161–77. PMID 16289898. doi:10.1016/j.mcn.2005.10.007.

Denne biokjemiartikkelen er ei spire. Du kan hjelpe Nynorsk Wikipedia gjennom å utvide han.

[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000123560 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000031425 - Ensembl, May 2017

[3] «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Jahn, Olaf; Tenzer, Stefan; Werner, Hauke B. (2009). «Myelin Proteomics: Molecular Anatomy of an Insulating Sheath». Molecular Neurobiology 40 (1): 55–72. PMC 2758371. PMID 19452287. doi:10.1007/s12035-009-8071-2.

[6] Torii, Tomohiro; Miyamoto, Yuki; Yamauchi, Junji; Tanoue, Akito (2014). «Pelizaeus-Merzbacher disease: Cellular pathogenesis and pharmacologic therapy». Pediatrics International 56 (5): 659. PMID 25040584. doi:10.1111/ped.12450.

[7] Baumann, N; Pham-Dinh, D (2001). «Biology of oligodendrocyte and myelin in the mammalian central nervous system». Physiological reviews 81 (2): 871–927. PMID 11274346.

[5-8] Daffu, Gurdip; Sohi, Jasloveleen; Kamholz, John (2012). «Proteolipid protein dimerization at cysteine 108: Implications for protein structure». Neuroscience Research 74 (2): 144. PMID 22902553. doi:10.1016/j.neures.2012.07.009.

[Fukumura2011-9] 9,0 ^9,1 Sarret, C.; Combes, P.; Micheau, P.; Gelot, A.; Boespflug-Tanguy, O.; Vaurs-Barriere, C. (2010). «Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene». Neuroscience 166 (2): 522. PMID 20036320. doi:10.1016/j.neuroscience.2009.12.047.

[10] Schweitzer, Jörn; Becker, Thomas; Schachner, Melitta; Nave, Klaus-Armin; Werner, Hauke (2006). «Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence». Molecular and Cellular Neuroscience 31 (1): 161–77. PMID 16289898. doi:10.1016/j.mcn.2005.10.007.

[5]

[6]

[7]

[8]

[9]

[1]

[2]

[3]

[4]

[10]