SOX10

SOX10
Identifikatorar
Andre namn	SOX10, DOM, PCWH, WS2E, WS4, WS4C, SRY-box 10, SRY-box transcription factor 10
Eksterne ID-ar	OMIM: 602229 MGI: 98358 HomoloGene: 5055 GeneCards: SOX10
Genplassering (menneske)
Kromosom	22
Ende	37,987,422 bp
Genplassering (mus)
Kromosom	Musekromosom 15
Ende	79,165,240 bp
RNA-uttrykksmønster
	; ;
	Meir referanseuttrykksdata
Genontologi
Molekylær funksjon	• GO:0001105 transcription coactivator activity; • transcription factor binding; • chromatin binding; • GO:0001948 proteinbinding; • identical protein binding; • promoter-specific chromatin binding; • DNA-binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Sellekomponent	• cytoplasma; • nukleoplasma; • cellekjerne; • kromatin; • mitokondrium; • mitochondrial outer membrane; • membran; • extrinsic component of mitochondrial outer membrane;
Biologisk prosess	• regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • morfogenese av anatomisk struktur; • transcription, DNA-templated; • stamcelledifferensiering; • negative regulation of transcription, DNA-templated; • transcription elongation from RNA polymerase II promoter; • negative regulation of Schwann cell proliferation; • positiv regulering av genekspresjon; • positive regulation of myelination; • cellular response to drug; • cellular response to progesterone stimulus; • positive regulation of transcription, DNA-templated; • oligodendrocyte development; • central nervous system myelination; • oligodendrocyte differentiation; • in utero embryonic development; • neural crest cell migration; • morfogenese av epitel; • positive regulation of neuroblast proliferation; • utvikling av sentralnervesystem; • peripheral nervous system development; • positive regulation of gliogenesis; • celledifferensiering; • melanocyte differentiation; • lacrimal gland development; • negativ regulering av apoptoseprosess; • positive regulation of transcription from RNA polymerase II promoter; • cellemodning; • enteric nervous system development; • digestive tract morphogenesis; • utviklingsvekst; • morphogenesis of a branching epithelium; • negative regulation of canonical Wnt signaling pathway;
	Kjelder:Amigo / QuickGO
Ortologar
	6663
	20665
	ENSG00000100146
	ENSMUSG00000033006
	P56693
	Q04888
	NM_006941
	NM_011437
	NP_008872
	NP_035567
	Wikidata
sjå/endra menneske	sjå/endra mus

SOX10 er ein transkripsjonsfaktor i SOX-genfamilien. Han er naudsynt for utvikling av både Schwann-seller og oligodendrocyttar.^[5] Han er òg naudsynt for utviklinga og vedlikehaldet av melanocyttar.^[6]

SOX10 har ulike bindingssete i oligodendrocyttar og Schwann-seller. I oligodendrocyttar vekselverkar SOX10 med protein som transkripsjonsfaktorane OLIG1, OLIG2 og myelinregulerande faktor. SOX10 bunde til OLIG1 aktiverer avskrivinga av genet til basisk myelinprotein (MBP). I Schwann-seller vekselverkar SOX10 med protein som transkripsjonsfaktoren tidleg vekstresponsprotein 2.^[5]^[7]

KjelderEndra

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000100146 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000033006 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:».
↑ «PubMed-kjelde for mus:».
↑ ^5,0 ^5,1 Lopez-Anido, Camila; Sun, Guannan; Koenning, Matthias; Srinivasan, Rajini; Hung, Holly A.; Emery, Ben; Keles, Sunduz; Svaren, John (2015). «Differential Sox10 genomic occupancy in myelinating glia». Glia 63 (11): 1897. doi:10.1002/glia.22855.
↑ Fufa, Temesgen D.; Harris, Melissa L.; Watkins-Chow, Dawn E.; Levy, Denise; Gorkin, David U.; Gildea, Derek E.; Song, Lingyun; Safi, Alexias; Crawford, Gregory E.; Sviderskaya, Elena V.; Bennett, Dorothy C.; McCallion, Andrew S.; Loftus, Stacie K.; Pavan, William J. (2015). «Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes». Human Molecular Genetics 24 (19): 5433. PMID 26206884. doi:10.1093/hmg/ddv267.
↑ Li, H.; Lu, Y.; Smith, H. K.; Richardson, W. D. (2007). «Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes». Journal of Neuroscience 27 (52): 14375. PMID 18160645. doi:10.1523/JNEUROSCI.4456-07.2007.

Denne biokjemiartikkelen er ei spire. Du kan hjelpe Nynorsk Wikipedia gjennom å utvide han.

[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000100146 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000033006 - Ensembl, May 2017

[3] «PubMed-kjelde for menneske:».

[4] «PubMed-kjelde for mus:».

[Lopez-Anido2015-5] 5,0 ^5,1 Lopez-Anido, Camila; Sun, Guannan; Koenning, Matthias; Srinivasan, Rajini; Hung, Holly A.; Emery, Ben; Keles, Sunduz; Svaren, John (2015). «Differential Sox10 genomic occupancy in myelinating glia». Glia 63 (11): 1897. doi:10.1002/glia.22855.

[6] Fufa, Temesgen D.; Harris, Melissa L.; Watkins-Chow, Dawn E.; Levy, Denise; Gorkin, David U.; Gildea, Derek E.; Song, Lingyun; Safi, Alexias; Crawford, Gregory E.; Sviderskaya, Elena V.; Bennett, Dorothy C.; McCallion, Andrew S.; Loftus, Stacie K.; Pavan, William J. (2015). «Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes». Human Molecular Genetics 24 (19): 5433. PMID 26206884. doi:10.1093/hmg/ddv267.

[7] Li, H.; Lu, Y.; Smith, H. K.; Richardson, W. D. (2007). «Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes». Journal of Neuroscience 27 (52): 14375. PMID 18160645. doi:10.1523/JNEUROSCI.4456-07.2007.

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