AXL-reseptoren

AXL
Tilgjengelege strukturar
PDB	Ortologsøk: PDBe RCSB
Liste over PDB-ID-kodar
	2C5D, 4RA0
Identifikatorar
Andre namn	AXL, AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase
Eksterne ID-ar	OMIM: 109135 MGI: 1347244 HomoloGene: 7583 GeneCards: AXL
Genplassering (menneske)
Kromosom	Menneskekromosom 19
Ende	41,261,766 bp
Genplassering (mus)
Kromosom	Musekromosom 7
Ende	25,488,130 bp
RNA-uttrykksmønster
	Top expressed in
	synovialledd; ; saphenous vein; ; stromal cell of endometrium; ; cartilage tissue; ; synovialhinne; ; urinrøyr; ; hjartepose; ; decidua; ; arteria poplitea; ; Tibial arteries;
	Meir referanseuttrykksdata
	; ;
	More reference expression data
Genontologi
Molekylær funksjon	nucleotide binding; proteinkinaseaktivitet; transferaseaktivitet; virus receptor activity; kinaseaktivitet; protein heterodimerization activity; ATP binding; phosphatidylserine binding; GO:0001948, GO:0016582 proteinbinding; transmembrane receptor protein tyrosine kinase activity; phosphatidylinositol 3-kinase binding; myosin heavy chain binding; protein tyrosine kinase activity; Wnt-protein binding;
Sellekomponent	ekstracellulært eksosom; integral component of membrane; host cell surface; integral component of plasma membrane; celleoverflate; membran; intracellulærrom; cellemembran; Ekstracellulærrom; reseptorkompleks;
Biologisk prosess	protein kinase B signaling; positive regulation of natural killer cell differentiation; apoptotic cell clearance; negative regulation of lymphocyte activation; spermatogenesis; negativ regulering av apoptoseprosess; GO:0072468 signaltransduksjon; natural killer cell differentiation; negative regulation of interferon-gamma production; cellular response to lipopolysaccharide; cellesekresjon; vascular endothelial growth factor receptor signaling pathway; substrate adhesion-dependent cell spreading; erythrocyte homeostasis; negative regulation of tumor necrosis factor production; positive regulation of protein kinase B signaling; GO:0022415 virusinfeksjon; positive regulation of cytokine-mediated signaling pathway; cellular response to interferon-alpha; forebrain cell migration; viral entry into host cell; negative regulation of dendritic cell apoptotic process; proteinfosforylering; cellular response to extracellular stimulus; enzyme linked receptor protein signaling pathway; positive regulation of pinocytosis; GO:1904089 negative regulation of neuron apoptotic process; vagina development; eggløysingssyklus; uspesifikk immunrespons; blood vessel remodeling; cellemodning; dendritic cell differentiation; blodplateaktivering; celledifferensiering; immunologisk prosess; inflammatorisk respons; neuron migration; fosforylering; cellular response to hydrogen peroxide; animal organ regeneration; Fagocytose; peptidyl-tyrosine phosphorylation; GO:0032697 negativ regulering av cytokinproduksjon; neutrophil clearance; transmembrane receptor protein tyrosine kinase signaling pathway; utvikling av nervesystem; Wnt signaling pathway; cellemigrasjon;
	Kjelder:Amigo / QuickGO
Ortologar
	558
	26362
	ENSG00000167601
	ENSMUSG00000002602
	P30530
	Q00993
	NM_001278599; NM_001699; NM_021913
	NM_001190974; NM_001190975; NM_009465
	NP_001265528; NP_001690; NP_068713
	NP_001177903; NP_001177904; NP_033491
	Wikidata
sjå/endra menneske	sjå/endra mus

AXL-reseptoren eller tyrosinproteinkinase reseptor UFO er ein reseptortyrosinkinase med vekstfaktoren GAS6 som ligand. Reseptoren er knytt til utvikling av kreft og verkar som eit inngangspunkta til sella for fleire virus.^[5]